Our expertise covers respiratory measurements, neuroimaging, and behavioral assessments in rodents.
We offer services in assessing opioid-induced respiratory depression using whole-body plethysmography in rodents, respiratory muscle recordings, and electroencephalography in rodents.
Please contact: gasp.lab@gmail.com for more information.
See this chapter for info: The Pathophysiology of Opioid-Induced Respiratory Depression. Handbook in Clinical Neurology. 2022. Montandon G.
We published numerous research articles using these approaches:
- µ-Opioid receptors in tachykinin-1-positive cells mediate the respiratory and antinociceptive effects of the opioid fentanyl. 2024. British Journal of Pharmacology. Furdui A, da Silveira Scarpellini C, Montandon G.
- Fentanyl-Induced Respiratory Depression and Locomotor Hyperactivity Are Mediated by μ-Opioid Receptors Expressed in Somatostatin-Negative Neurons. eNeuro. Jun 28;10(6): 2023. Furdui A, da Silveira Scarpellini C, Montandon G.
- Medullary tachykinin precursor 1 neurons promote rhythmic breathing. eLife. Jul 17;12: e85575. 2023. Rousseau JP, Furdui A, Silveira Scarpellini CD, Horner RL, Montandon G.
- βγ G-proteins, but not regulators of G-protein signaling 4, modulate opioid-induced respiratory rate depression. Frontiers in Physiology. Apr 6;14:1043581. 2023. Danaf J, da Silveira Scarpellini C, Montandon G.
We also assess opioid receptor expression in many brain regions using in-situ hybridization:
- Anatomical distribution of µ-opioid receptors, neurokinin-1 receptors, and vesicular glutamate transporter 2 in the mouse brainstem respiratory network. Journal of Neurophysiology. May 15. doi: 10.1152/jn.00478.2023. PMID: 38748514. 2024. Furdui A, da Silveira Scarpellini C, Montandon G.
We have been contracted by private biomedical companies and have extensive experience providing services related to respiratory physiology and drug discovery.
